KAND/REN analysis updates
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What is the maximal feasible match given the surveys permutations? Create list of feasible phenotypes from the Cpath data to match (Tmax) to gold standard. create a comprehensive list of questions could address each phenotype: may be mulitple (or none). -
Create a Tmax set for Tuberous Sclerosis and Lennox-Gastaut to test disease to phenotype matching for epilepsy vs non-epilepsy conditions within the REN data. -
Examine existing docs for KAND/REN and look for possible exclusions like ‘other’ diagnoses/phenotypes as well as context of diseases vs phenotypes and replace terms where necessary. -
Rerun analysis against new API with improved data/context. -
Are there questions that are related to diagnosis that are missing from the gold standard? Decide if it is a relevant phenotype (gap) or extraneous symptom (exclude) through literature search (or potential CME help?).